abstract：BACKGROUND:The pleiotropic cytokine osteopontin (OPN) is thought to be involved in the pathogenesis of atherosclerosis. However, the relationship between OPN and renal function, a cardiovascular risk factor itself, is not known. Therefore, we assessed the relationship between OPN plasma levels and renal function in pat...

journal_title：European journal of clinical investigation

authors： Lorenzen J,Krämer R,Kliem V,Bode-Boeger SM,Veldink H,Haller H,Fliser D,Kielstein JT

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Arterial stiffness is an important determinant of cardiovascular risk. It is associated with several cardiovascular risk factors, including hypertension, diabetes and cigarette smoking. However, there are conflicting data about the relationship between arterial stiffness and hypercholesterolemia. Furthermore...

journal_title：European journal of clinical investigation

authors： Riggio S,Mandraffino G,Sardo MA,Iudicello R,Camarda N,Imbalzano E,Alibrandi A,Saitta C,Carerj S,Arrigo T,Saitta A

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the effect of alpha-lipoic acid (ALA) treatment on endothelium-dependent and -independent vasodilatation, assessed by forearm blood flow (FBF), in patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS:A total of 30 subjects with type 2 diabetes were incl...

journal_title：European journal of clinical investigation

authors： Heinisch BB,Francesconi M,Mittermayer F,Schaller G,Gouya G,Wolzt M,Pleiner J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The aim was to examine whether the inhibition of selective cyclooxygenase (COX) 2 activation could suppress the development of inflammatory reaction in visceral and subcutaneous abdominal fats of high-fat-induced obese rats. MATERIALS AND METHODS:The rats were fed separately regular diet (CONT), high-fat di...

journal_title：European journal of clinical investigation

authors： Hsieh PS,Lu KC,Chiang CF,Chen CH

更新日期：2010-02-01 00:00:00

abstract：:Arterial lumen narrowing and vascular occlusion is the actual cause of morbidity and mortality in atherosclerotic disease. Collateral artery formation (arteriogenesis) refers to an active remodelling of non-functional vascular anastomoses to functional collateral arteries, capable to bypass the site of obstruction and...

journal_title：European journal of clinical investigation

authors： de Groot D,Pasterkamp G,Hoefer IE

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Many studies have focused on the physiological parameters and genetic predisposition of subjects presenting both obesity and insulin resistance (IR) and it has been suggested that the peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) Pro12Ala variant may contribute to the observed variability i...

journal_title：European journal of clinical investigation

authors： Macias-Gonzalez M,Moreno-Santos I,García-Almeida JM,Tinahones FJ,Garcia-Fuentes E

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Recent studies in mice experimental models with acute ischaemic injury revealed that erythropoietin (EPO) has numerous tissue-protective effects in the heart, brain and kidneys. We therefore explored the tissue-protective properties of chronic EPO treatment in an experimental model of the db/db mouse with di...

journal_title：European journal of clinical investigation

authors： Shushakova N,Park JK,Menne J,Fliser D

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Angiotensin converting enzyme 2 (ACE2), a monocarboxylase that degrades angiotensin II to angiotensin 1-7, is also the functional receptor for severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) and is highly expressed in the lungs and heart. Patients with SARS also suffered from cardiac disease ...

journal_title：European journal of clinical investigation

authors： Oudit GY,Kassiri Z,Jiang C,Liu PP,Poutanen SM,Penninger JM,Butany J

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is followed by post AMI cardiac remodelling, often leading to congestive heart failure. Homing of c-kit+ endothelial progenitor cells (EPC) has been thought to be the optimal source for regenerating infarcted myocardium. METHODS:Immune function of viable peripheral blood mo...

journal_title：European journal of clinical investigation

authors： Ankersmit HJ,Hoetzenecker K,Dietl W,Soleiman A,Horvat R,Wolfsberger M,Gerner C,Hacker S,Mildner M,Moser B,Lichtenauer M,Podesser BK

更新日期：2009-06-01 00:00:00

abstract：:The saphenous vein is the most commonly used graft for revascularization procedures in patients with coronary artery disease and critical limb ischaemia. However, the patency rate of this vessel is poor, with a high proportion of patients requiring further surgery. Early graft occlusion is caused by vasoconstriction o...

journal_title：European journal of clinical investigation

authors： Dashwood MR

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The mammalian target of rapamycin (mTOR) has recently been implicated in leukaemic cell growth, tumour-associated angiogenesis and expression of vascular endothelial growth factor (VEGF). We examined whether mTOR plays a role as regulator of growth and VEGF-expression in acute myeloid leukaemia (AML). Three ...

journal_title：European journal of clinical investigation

authors： Böhm A,Aichberger KJ,Mayerhofer M,Herrmann H,Florian S,Krauth MT,Derdak S,Samorapoompichit P,Sonneck K,Vales A,Gleixner KV,Pickl WF,Sperr WR,Valent P

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Thyroid hormone has important effects on the cardiovascular system. The consequences of episodes of acute hypothyroidism on cardiac function have been investigated in only a few studies, and their results are inconclusive. Our objective was to investigate the effects of acute hypothyroidism on cardiac functi...

journal_title：European journal of clinical investigation

authors： Hoftijzer HC,Bax JJ,Heemstra KA,Bleeker GB,Delgado V,van der Klaauw AA,Romijn JA,Smit JW,Corssmit EP

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Changes in bile acid (BA) pool, such as the reappearance of typically foetal-type molecular species with a 'flat' structure at the steroid ring, occur during hepatocarcinogenesis, both in humans and rodents. Moreover flat-BAs also appear during rat liver regeneration. These changes can be detected in urine. ...

journal_title：European journal of clinical investigation

authors： Stärkel P,Shindano T,Horsmans Y,Gigot JF,Fernandez-Tagarro M,Marin JJ,Monte MJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Recent data suggest that, among other factors, comorbidity may be an important prognostic variable in patients with myelodysplastic syndromes (MDS) who are eligible for haematopoietic stem cell transplantation (SCT). PATIENTS AND METHODS:We examined the overall survival (OS) and underlying risk factors in 4...

journal_title：European journal of clinical investigation

authors： Boehm A,Sperr WR,Leitner G,Worel N,Oehler L,Jaeger E,Mitterbauer M,Haas OA,Valent P,Kalhs P,Rabitsch W

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Adiponectin is an insulin-sensitizing, antiatherogenic and anti-inflammatory adipocytokine that circulates in three isoforms: a trimer [low-molecular weight (LMW)], a hexamer (trimer-dimer) of medium molecular weight (MMW) and a multimeric high molecular weight (HMW) isoform. Evidence is accumulating that HM...

journal_title：European journal of clinical investigation

authors： Kaser S,Tatarczyk T,Stadlmayr A,Ciardi C,Ress C,Tschoner A,Sandhofer A,Paulweber B,Ebenbichler CF,Patsch JR

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Fat tissue is a common material for autologous transplantation in plastic and reconstructive surgery. Basic fibroblast growth factor (bFGF) ameliorates the fat graft survival. A transplantation model has shown the gene expression of matrix metalloproteinases (MMPs) to increase in adipocytes. The aim of this ...

journal_title：European journal of clinical investigation

authors： Kuramochi D,Unoki H,Bujo H,Kubota Y,Jiang M,Rikihisa N,Udagawa A,Yoshimoto S,Ichinose M,Saito Y

更新日期：2008-10-01 00:00:00

abstract：:Acute renal failure is a grave complication of systemic gram-negative sepsis. The pathophysiological mechanisms of sepsis leading to kidney injury result in part from systemic inflammatory and haemodynamic alterations. These are triggered by the interaction of endotoxin with Toll-like receptor 4 (TLR4) on cells of the...

journal_title：European journal of clinical investigation

authors： El-Achkar TM,Hosein M,Dagher PC

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Portal endotoxaemia has been speculated to be crucially involved in the pathogenesis of chronic hepatic inflammation, which is highly associated with the development of type 2 diabetes mellitus. This study tests whether portal endotoxaemia is a pathogenic link between chronic subacute hepatic inflammation an...

journal_title：European journal of clinical investigation

authors： Hsieh PS,Chan JY,Shyu JF,Chen YT,Loh CH

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The accuracy of estimating glomerular filtration rate from plasma creatinine (eGFR) has been questioned but it is unclear how much covert error in several reference methods that have been used has contributed to this perceived inaccuracy. The aim of the study was to evaluate eGFR in comparison with a second ...

journal_title：European journal of clinical investigation

authors： Bird NJ,Peters C,Michell AR,Peters AM

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Although several lines of evidence suggest that hypomagnesaemia is a risk factor for developing type 2 diabetes, there are no studies regarding the association between hypomagnesaemia and the risk for developing impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). Our objective was to examine ...

journal_title：European journal of clinical investigation

authors： Guerrero-Romero F,Rascón-Pacheco RA,Rodríguez-Morán M,de la Peña JE,Wacher N

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Weight loss induced by bariatric surgery is an effective method to reverse obesity and comorbidities. The aim of this prospective weight loss study was to investigate changes of body fat distribution in relation to adiponectin and its isoforms and further to investigate the influence of both body fat distrib...

journal_title：European journal of clinical investigation

authors： Engl J,Sturm W,Sandhofer A,Kaser S,Tschoner A,Tatarczyk T,Weiss H,Tilg H,Patsch JR,Ebenbichler CF

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:It has been speculated that oral hypoglycaemic agents that block K-ATP channels could potentially increase blood pressure by blocking such channels in vascular myocytes. No information about this issue exists regarding nateglinide. DESIGN:A multicentre, double-blind, placebo-controlled, randomized trial was...

journal_title：European journal of clinical investigation

authors： González-Clemente JM,Spanish Nateglinide Study Group.

更新日期：2008-03-01 00:00:00

abstract：:Transfusion-related morbidity is an emerging challenge in chronically transfused patients with low-risk myelodysplastic syndromes (MDS). In these patients, transfusion-induced iron overload may represent a leading medical problem. However, although iron-chelating drugs are available, little is known about optimal diag...

journal_title：European journal of clinical investigation

authors： Valent P,Krieger O,Stauder R,Wimazal F,Nösslinger T,Sperr WR,Sill H,Bettelheim P,Pfeilstöcker M

更新日期：2008-03-01 00:00:00

abstract：:Both ulcerative colitis and Crohn's disease, the two major forms of inflammatory bowel diseases, are recognized, at the moment, as perplexing and challenging clinical entities, in which several molecules and cell types are implicated. Recent molecular evidence proposes the intestinal microvascular remodelling or angio...

journal_title：European journal of clinical investigation

authors： Pousa ID,Maté J,Gisbert JP

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Recent data suggest that the mammalian target of rapamycin (mTOR) is involved in the regulation of growth of neoplastic cells in chronic myeloid leukaemia (CML). PATIENTS AND METHODS:We treated six patients with imatinib-resistant CML in haematological relapse (leukocytes > 20,000 microL(-1)) with rapamycin...

journal_title：European journal of clinical investigation

authors： Sillaber C,Mayerhofer M,Böhm A,Vales A,Gruze A,Aichberger KJ,Esterbauer H,Pfeilstöcker M,Sperr WR,Pickl WF,Haas OA,Valent P

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:In inflammatory bowel diseases, changes in autonomic enteric regulation may also affect neural cardiovascular control. However, while cardiac autonomic modulation has been shown to be impaired in active ulcerative colitis, the occurrence of cardiovascular autonomic alterations, also in the quiescent phase of...

journal_title：European journal of clinical investigation

authors： Coruzzi P,Castiglioni P,Parati G,Brambilla V,Brambilla L,Gualerzi M,Cademartiri F,Franzè A,De Angelis G,Di Rienzo M,Di Mario F

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Disuse and/or local inflammation in the muscle cannot be excluded as potential influences for the decreased muscle force in patients hospitalised due to an acute chronic obstructive pulmonary disease (COPD) exacerbation. This study aims to compare expression levels of markers of disuse (insulin-like growth f...

journal_title：European journal of clinical investigation

authors： Crul T,Spruit MA,Gayan-Ramirez G,Quarck R,Gosselink R,Troosters T,Pitta F,Decramer M

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Bone marrow-derived circulating progenitor cells (BM-CPCs) are mobilized into adult peripheral blood (PB) during acute myocardial infarction (AMI) and may contribute to the regeneration of infarcted myocardium. The purpose of the present study is to determine whether mobilization of BM-CPCs into PB depends o...

journal_title：European journal of clinical investigation

authors： Turan RG,Brehm M,Koestering M,Tobias Z,Bartsch T,Steiner S,Picard F,Ebner P,Schannwell CM,Strauer BE

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND:Expression of acinar cell-specific genes requires the pancreas transcription factor 1alpha (Ptf1alpha). p48 is the only component of Ptf1alpha that is involved in both acinar gene regulation and pancreatic ontogenesis. MATERIALS AND METHODS:To determine whether Ptf1alpha/p48 expression is regulated during p...

journal_title：European journal of clinical investigation

authors： Molero X,Adell T,Skoudy A,Padilla MA,Gómez JA,Chalaux E,Malagelada JR,Real FX

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Insulin resistance significantly correlated with a non-dipper type of essential hypertension. Thiazolidinediones (TZD), oral hypoglycaemic agents that act as insulin sensitizers, have been demonstrated in multiple in vivo and in vitro studies to possess antihypertensive properties. This study examined the ef...

journal_title：European journal of clinical investigation

authors： Anan F,Masaki T,Fukunaga N,Teshima Y,Iwao T,Kaneda K,Umeno Y,Okada K,Wakasugi K,Yonemochi H,Eshima N,Saikawa T,Yoshimatsu H

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Mutations in endoglin (ENG) and activin receptor-like kinase 1 (ALK-1 or ACVRL1) genes are the underlying basis of hereditary haemorrhagic telangiectasia (HHT) types 1 and 2, respectively. Both genes belong to the transforming growth factor-beta (TGF-beta) receptors superfamily and are expressed in endotheli...

journal_title：European journal of clinical investigation

authors： Thomas B,Eyries M,Montagne K,Martin S,Agrapart M,Simerman-François R,Letarte M,Soubrier F

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The aetiology of inguinal hernia includes changes in collagen turnover and metalloproteinase (MMP) expression, and direct hernia has been linked to increased MMP-2 expression. Since transforming growth factor beta1 (TGFbeta1) plays a role in tissue remodelling, this growth factor could directly affect metall...

journal_title：European journal of clinical investigation

authors： Pascual G,Corrales C,Gómez-Gil V,Buján J,Bellón JM

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:In dialysis patients, cardiac troponin T (cTNT) is often elevated despite the absence of acute myocardial ischaemia, and amino-terminal pro-B-natriuretic peptide (NT-proBNP) is markedly higher compared to non-haemodialysis patients. In a longitudinal observation, we evaluated the association of cTNT and NT-p...

journal_title：European journal of clinical investigation

authors： Sommerer C,Beimler J,Schwenger V,Heckele N,Katus HA,Giannitsis E,Zeier M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Plasma brain natriuretic peptide (BNP) is elevated in asymptomatic patients with various cardiac abnormalities. We tested the hypothesis that measuring BNP is useful for detecting asymptomatic patients with cardiac abnormalities who are not identified by conventional health check-up programmes. MATERIALS AN...

journal_title：European journal of clinical investigation

authors： Takase H,Toriyama T,Sugiura T,Takahashi A,Sugiyama M,Ohashi M,Ueda R,Dohi Y

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:A broad spectrum of hepatobiliary disorders are found in patients with inflammatory bowel diseases. The aim of the present work was to study interactions between gut and liver in experimental rat models of colitis and small bowel inflammation. MATERIALS AND METHODS:Colitis was induced either by trinitrobenz...

journal_title：European journal of clinical investigation

authors： Dikopoulos N,Schmid RM,Bachem M,Buttenschoen K,Adler G,Chiang JY,Weidenbach H

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Nasal nitric oxide (nNO) values are reduced in patients with cystic fibrosis (CF). Humming during nNO measurement increases nNO values in healthy subjects. Nasal NO is reduced in patients with CF, sinus disease or nasal polyps. Humming nNO values have not been reported in CF patients yet. Our aim was to expl...

journal_title：European journal of clinical investigation

authors： Struben VM,Sewbalak WV,Wieringa MH,Mantingh CJ,van den Toorn LM,Bakker M,Feenstra L,de Jongste JC

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:CD33 (Siglec-3) is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML). In normal myelopoiesis, expression of CD33 is restricted to advanced stages of differentiation, whereas primitive stem cells do not express CD33. In the present study, we asked whethe...

journal_title：European journal of clinical investigation

authors： Hauswirth AW,Florian S,Printz D,Sotlar K,Krauth MT,Fritsch G,Schernthaner GH,Wacheck V,Selzer E,Sperr WR,Valent P

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Inflammation is an established contributor in atherosclerosis and several other common diseases including diabetes. Therefore the study was to investigate how inflammatory factors affect lipid metabolism during recovery from hyperinsulinaemia in healthy individuals. MATERIALS AND METHODS:A total of 22 healt...

journal_title：European journal of clinical investigation

authors： Heliövaara MK,Teppo AM,Karonen SL,Ebeling P

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss of higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques (SPs) of aggregated amyloid-beta peptide (Abeta) and intracellular neurofibrillary tangles ...

journal_title：European journal of clinical investigation

authors： Yokota T,Mishra M,Akatsu H,Tani Y,Miyauchi T,Yamamoto T,Kosaka K,Nagai Y,Sawada T,Heese K

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The transit time of the small intestine, in addition to lactase activity, may influence lactose digestion and thus play a role in the occurrence of lactose intolerance. The objectives of this study were to investigate the effect of lactose on the oro-cecal transit time (OCTT) in lactose digesters and maldige...

journal_title：European journal of clinical investigation

authors： He T,Priebe MG,Welling GW,Vonk RJ

更新日期：2006-10-01 00:00:00